In computer science and engineering education, teaching PC interfacing syllabuses and laboratory experiments are strongly required. PC interfacing is the field of developing or simulating real/virtual solutions for exchanging data/commands between PC and the outer world of sensors and actuators. Recently, virtual experiments and Labs are adopted by engineering educators to prevent the physical presence of students and tutors and to provide effective skills acquisition and hands-on experience in a virtual manner. Highly cost LabVIEW from National Instruments (NI) company is the dominant platform to develop, execute, and animate virtual PC interfacing experiments similarly as real ones. This course presents a toolchain, the syllabus contents, and virtual experiments that cover many different PC interfacing technologies such as UART, SPI, RS232, USB, SD card interfacing, and wireless GSM/GPRS. The virtual nature of this course toolchain refers to enable the students to design, animate, and run their prototypes or solutions inside only PC programs without the need to build physical or real ones until making sure of their prototypes functionality. The main aim of the course platform is to make students able of developing C# based applications and to implement solutions with an aesthetic look similar to LabVIEW capabilities to become a low-cost alternative to it. This course includes a group of free of charge and third-party software programs such as virtual serial port driver, Virtual USB driver, WinImage, and Real-Term alongside with Proteus simulator and C# programming language. These third-party programs can be employed as a nexus between Proteus simulator and C#-based applications to provide virtual communication channels between them.