Evidence-based Toxicology

Welcome to the Evidence-based Toxicology (EBT) course. In medicine and healthcare, evidence-based medicine has revolutionized the way that information is evaluated transparently and objectively. Over the past ten years, a movement in North America and Europe has attempted to translate this revolution to the field of toxicology.The Center for Alternatives to Animal Testing (CAAT) within the department of Environmental Health and Engineering at the Johns Hopkins Bloomberg School of Public Health hosts the first chair for EBT and the secretariat for the EBT Collaboration on both sides of the Atlantic. Based on the Cochrane Collaboration in Evidence-based Medicine, the EBT Collaboration was established at the CAAT to foster the development of a process for quality assurance of new toxicity tests for the assessment of safety in humans and the environment. Regulatory safety sciences have undergone remarkably little change in the past fifty years. At the same time, our knowledge in the life sciences is doubling about every seven years. Systematic review and related evidence-based approaches are beginning to be adapted by regulatory agencies like the Environment Protection Agency (EPA), the European Food Safety Authority (EFSA), and the US National Toxicology Program. They provide transparent, objective, and consistent tools to identify, select, appraise, and extract evidence across studies. This course will showcase these emerging efforts and address opportunities and challenges to the expanded use of these tools within toxicology.

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Syllabus

Syllabus - What you will learn from this course
Week 1
Introduction & Shortcomings of Current Approaches
Week 2
History and Causation
Week 3
Systematic Review and Meta-Analysis
Week 4
Risk of Bias & Application to Test Methods Comparison
Week 5
Quality Assurance, Good Practices, and Validation
Week 6
Biometrical Tools & Future Perspectives
Week 7
Summative Assessment - Systematic Review Assignment

FAQ

When will I have access to the lectures and assignments?

Access to lectures and assignments depends on your type of enrollment. If you take a course in audit mode, you will be able to see most course materials for free. To access graded assignments and to earn a Certificate, you will need to purchase the Certificate experience, during or after your audit. If you don't see the audit option:

The course may not offer an audit option. You can try a Free Trial instead, or apply for Financial Aid.

The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.

What will I get if I purchase the Certificate?

When you purchase a Certificate you get access to all course materials, including graded assignments. Upon completing the course, your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile. If you only want to read and view the course content, you can audit the course for free.

Is financial aid available?

Yes. In select learning programs, you can apply for financial aid or a scholarship if you can’t afford the enrollment fee. If fin aid or scholarship is available for your learning program selection, you’ll find a link to apply on the description page.

Reviews

Surprisingly very informative and detailed Course. Thanks for the load of information given.

Thanks for the opportunity to be part of those who will benefit from their awesome course.

Quite informative and exposed me to a whole new horizon in the ever blooming world of toxicology. I would like to thank Dr. Thomas Hartung and his team at John Hopkins for making this possible!

Excellent, it has given me a very clear and complete vision.gave me a very clear and complete picture.